Oocytes mount a noncanonical DNA damage response involving APC-Cdh1–mediated proteolysis

In mitotic cells, DNA damage induces temporary G2 arrest via inhibitory Cdk1 phosphorylation. In contrast, fully grown G2-stage oocytes readily enter M phase immediately following chemical induction of DNA damage in vitro, indicating that the canonical immediate-response G2/M DNA damage response (DD...

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Bibliografske podrobnosti
izdano v:J Cell Biol
Main Authors: Subramanian, Goutham Narayanan, Greaney, Jessica, Wei, Zhe, Becherel, Olivier, Lavin, Martin, Homer, Hayden Anthony
Format: Artigo
Jezik:Inglês
Izdano: Rockefeller University Press 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7147104/
https://ncbi.nlm.nih.gov/pubmed/32328643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201907213
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