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Oocytes mount a noncanonical DNA damage response involving APC-Cdh1–mediated proteolysis
In mitotic cells, DNA damage induces temporary G2 arrest via inhibitory Cdk1 phosphorylation. In contrast, fully grown G2-stage oocytes readily enter M phase immediately following chemical induction of DNA damage in vitro, indicating that the canonical immediate-response G2/M DNA damage response (DD...
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7147104/ https://ncbi.nlm.nih.gov/pubmed/32328643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201907213 |
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