The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA damage response checkpoint

In response to DNA damage in G2, mammalian cells must avoid entry into mitosis and instead initiate DNA repair. Here we show that in response to genotoxic stress in G2, the phosphatase Cdc14B translocates from the nucleolus to the nucleoplasm and induces the activation of the ubiquitin ligase APC/C(...

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Hauptverfasser: Bassermann, Florian, Frescas, David, Guardavaccaro, Daniele, Busino, Luca, Peschiaroli, Angelo, Pagano, Michele
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2591934/
https://ncbi.nlm.nih.gov/pubmed/18662541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.05.043
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