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The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA damage response checkpoint
In response to DNA damage in G2, mammalian cells must avoid entry into mitosis and instead initiate DNA repair. Here we show that in response to genotoxic stress in G2, the phosphatase Cdc14B translocates from the nucleolus to the nucleoplasm and induces the activation of the ubiquitin ligase APC/C(...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2591934/ https://ncbi.nlm.nih.gov/pubmed/18662541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.05.043 |
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