Enzyme Replacement Therapy Prevents Dental Defects in a Model of Hypophosphatasia

Hypophosphatasia (HPP) occurs from loss-of-function mutation in the tissue-non-specific alkaline phosphatase (TNALP) gene, resulting in extracellular pyrophosphate accumulation that inhibits skeletal and dental mineralization. TNALP-null mice (Akp2(-/-)) phenocopy human infantile hypophosphatasia; t...

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Autors principals: McKee, M.D., Nakano, Y., Masica, D.L., Gray, J.J., Lemire, I., Heft, R., Whyte, M.P., Crine, P., Millán, J.L.
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2011
Matèries:
Research Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144124/
https://ncbi.nlm.nih.gov/pubmed/21212313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0022034510393517
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