Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme

We identified hyaluronan synthase-2 (Has2) as a likely source of hyaluronan (HA) during embryonic development, and we used gene targeting to study its function in vivo. Has2(–/–) embryos lack HA, exhibit severe cardiac and vascular abnormalities, and die during midgestation (E9.5–10). Heart explants...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Camenisch, Todd D., Spicer, Andrew P., Brehm-Gibson, Tammy, Biesterfeldt, Jennifer, Augustine, Mary Lou, Calabro, Anthony, Kubalak, Steven, Klewer, Scott E., McDonald, John A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2000
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC314332/
https://ncbi.nlm.nih.gov/pubmed/10930438
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi