Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits

We examined the role of cyclooxygenase-2 (COX-2) in the late phase of ischemic preconditioning (PC). A total of 176 conscious rabbits were used. Ischemic PC (six cycles of 4-min coronary occlusions/4-min reperfusions) resulted in a rapid increase in myocardial COX-2 mRNA levels (+231 ± 64% at 1 h; R...

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Detalhes bibliográficos
Main Authors: Shinmura, Ken, Tang, Xian-Liang, Wang, Yang, Xuan, Yu-Ting, Liu, Si-Qi, Takano, Hitoshi, Bhatnagar, Aruni, Bolli, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC27805/
https://ncbi.nlm.nih.gov/pubmed/10963682
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