Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits

We examined the role of cyclooxygenase-2 (COX-2) in the late phase of ischemic preconditioning (PC). A total of 176 conscious rabbits were used. Ischemic PC (six cycles of 4-min coronary occlusions/4-min reperfusions) resulted in a rapid increase in myocardial COX-2 mRNA levels (+231 ± 64% at 1 h; R...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Shinmura, Ken, Tang, Xian-Liang, Wang, Yang, Xuan, Yu-Ting, Liu, Si-Qi, Takano, Hitoshi, Bhatnagar, Aruni, Bolli, Roberto
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27805/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10963682/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.18.10197
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