Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme

We identified hyaluronan synthase-2 (Has2) as a likely source of hyaluronan (HA) during embryonic development, and we used gene targeting to study its function in vivo. Has2(–/–) embryos lack HA, exhibit severe cardiac and vascular abnormalities, and die during midgestation (E9.5–10). Heart explants...

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Autors principals: Camenisch, Todd D., Spicer, Andrew P., Brehm-Gibson, Tammy, Biesterfeldt, Jennifer, Augustine, Mary Lou, Calabro, Anthony, Kubalak, Steven, Klewer, Scott E., McDonald, John A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2000
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC314332/
https://ncbi.nlm.nih.gov/pubmed/10930438
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