Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme

We identified hyaluronan synthase-2 (Has2) as a likely source of hyaluronan (HA) during embryonic development, and we used gene targeting to study its function in vivo. Has2(–/–) embryos lack HA, exhibit severe cardiac and vascular abnormalities, and die during midgestation (E9.5–10). Heart explants...

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Vydáno v:	J Clin Invest
Hlavní autoři:	Camenisch, Todd D., Spicer, Andrew P., Brehm-Gibson, Tammy, Biesterfeldt, Jennifer, Augustine, Mary Lou, Calabro, Anthony, Kubalak, Steven, Klewer, Scott E., McDonald, John A.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical Investigation 2000
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314332/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10930438/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI10272
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