Treatment of murine lupus with cDNA encoding IFN-γR/Fc

IFN-γ, a pleiotropic cytokine, is a key effector molecule in the pathogenesis of several autoimmune diseases, including lupus. Importantly, deletion of IFN-γ or IFN-γR in several lupus-predisposed mouse strains resulted in significant disease reduction, suggesting the potential for therapeutic inter...

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Опубликовано в::	J Clin Invest
Главные авторы:	Lawson, Brian R., Prud’homme, Gerald J., Chang, Yigang, Gardner, Humphrey A., Kuan, Jason, Kono, Dwight H., Theofilopoulos, Argyrios N.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Clinical Investigation 2000
Предметы:	Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314313/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10903336/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI10167
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