Treatment of murine lupus with cDNA encoding IFN-γR/Fc

IFN-γ, a pleiotropic cytokine, is a key effector molecule in the pathogenesis of several autoimmune diseases, including lupus. Importantly, deletion of IFN-γ or IFN-γR in several lupus-predisposed mouse strains resulted in significant disease reduction, suggesting the potential for therapeutic inter...

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Main Authors: Lawson, Brian R., Prud’homme, Gerald J., Chang, Yigang, Gardner, Humphrey A., Kuan, Jason, Kono, Dwight H., Theofilopoulos, Argyrios N.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2000
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC314313/
https://ncbi.nlm.nih.gov/pubmed/10903336
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