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PD-1 blockade by CT-011, anti PD-1 antibody, enhances ex-vivo T cell responses to autologous dendritic/myeloma fusion vaccine

We have developed a cancer vaccine in which autologous tumor is fused with dendritic cells (DCs) resulting in the presentation of tumor antigens in the context of DC mediated costimulation. In clinical trials, immunologic responses have been observed, however responses may be muted by inhibitory pat...

詳細記述

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書誌詳細
主要な著者: Rosenblatt, Jacalyn, Glotzbecker, Brett, Mills, Heidi, Vasir, Baldev, Tzachanis, Dimitrios, Levine, James D., Joyce, Robin M., Wellenstein, Kerry, Keefe, Whitney, Schickler, Michael, Rotem-Yehudar, Rinat, Kufe, Donald, Avigan, David
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142955/
https://ncbi.nlm.nih.gov/pubmed/21577144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e31821ca6ce
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