PD-1 blockade by CT-011, anti PD-1 antibody, enhances ex-vivo T cell responses to autologous dendritic/myeloma fusion vaccine

We have developed a cancer vaccine in which autologous tumor is fused with dendritic cells (DCs) resulting in the presentation of tumor antigens in the context of DC mediated costimulation. In clinical trials, immunologic responses have been observed, however responses may be muted by inhibitory pat...

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Bibliografiska uppgifter
Huvudupphovsmän: Rosenblatt, Jacalyn, Glotzbecker, Brett, Mills, Heidi, Vasir, Baldev, Tzachanis, Dimitrios, Levine, James D., Joyce, Robin M., Wellenstein, Kerry, Keefe, Whitney, Schickler, Michael, Rotem-Yehudar, Rinat, Kufe, Donald, Avigan, David
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142955/
https://ncbi.nlm.nih.gov/pubmed/21577144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e31821ca6ce
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