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Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination
Fast axonal conduction depends on myelin, which is formed by Schwann cells in the PNS. We found that the transcription factor Yin Yang 1 (YY1) is crucial for peripheral myelination. Conditional ablation of Yy1 in the Schwann cell lineage resulted in severe hypomyelination, which occurred independent...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3142946/ https://ncbi.nlm.nih.gov/pubmed/21057508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2686 |
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