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Incidental CD8 T cell reactivity against caspase-cleaved apoptotic self-antigens from ubiquitously expressed proteins in islets from prediabetic human leucocyte antigen-A2 transgenic non-obese diabetic mice
Apoptosis is known as a major mechanism which contributes to beta cell decay in type 1 diabetes. Commitment to this pathway generally involves caspase-mediated protein cleavage and was found to induce cross-presentation of a specific antigen repertoire under certain inflammatory conditions. We aimed...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3142640/ https://ncbi.nlm.nih.gov/pubmed/21605113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2011.04420.x |
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