DNA Immunization with Fusion of CTLA-4 to Hepatitis B Virus (HBV) Core Protein Enhanced Th2 Type Responses and Cleared HBV with an Accelerated Kinetic

BACKGROUND: Typically, DNA immunization via the intramuscular route induces specific, Th1-dominant immune responses. However, plasmids expressing viral proteins fused to cytotoxic T lymphocyte antigen 4 (CTLA-4) primed Th2-biased responses and were able to induced effective protection against viral...

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Главные авторы: Yin, Ying, Wu, Chunchen, Song, Jingjiao, Wang, Junzhong, Zhang, Ejuan, Liu, Hongyan, Yang, Dongliang, Chen, Xinwen, Lu, Mengji, Xu, Yang
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142188/
https://ncbi.nlm.nih.gov/pubmed/21799884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022524
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