The dose of HBV genome contained plasmid has a great impact on HBV persistence in hydrodynamic injection mouse model

BACKGROUND: Hydrodynamic injection (HI) of hepatitis B virus (HBV) mouse model is an useful tool for HBV related research in vivo. However, only 40% of C57/BL6 mice injected with 10 μg HBV genome contained plasmid (pAAV-HBV1.2), serum HBsAg more than 6 months and none of the BALB/c mice injected wit...

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Detalhes bibliográficos
Publicado no:Virol J
Main Authors: Li, Lei, Li, Sheng, Zhou, Yun, Yang, Lu, Zhou, Di, Yang, Yan, Lu, Mengji, Yang, Dongliang, Song, Jingjiao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5657044/
https://ncbi.nlm.nih.gov/pubmed/29070073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-017-0874-6
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