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p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
p53-mediated transcription activity is essential for cell cycle arrest, but its importance for apoptosis remains controversial. To address this question, we employed homologous recombination and LoxP/Cre-mediated deletion to produce mutant murine embryonic stem (ES) cells that express p53 with Gln a...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314218/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10990460/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.18.4967 |
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