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p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
p53-mediated transcription activity is essential for cell cycle arrest, but its importance for apoptosis remains controversial. To address this question, we employed homologous recombination and LoxP/Cre-mediated deletion to produce mutant murine embryonic stem (ES) cells that express p53 with Gln a...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2000
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC314218/ https://ncbi.nlm.nih.gov/pubmed/10990460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.18.4967 |
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