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p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

p53-mediated transcription activity is essential for cell cycle arrest, but its importance for apoptosis remains controversial. To address this question, we employed homologous recombination and LoxP/Cre-mediated deletion to produce mutant murine embryonic stem (ES) cells that express p53 with Gln a...

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Udgivet i:EMBO J
Principais autores: Chao, Connie, Saito, Shin’ichi, Kang, Jian, Anderson, Carl W., Appella, Ettore, Xu, Yang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2000
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314218/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10990460/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.18.4967
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