Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-κB-dependent gene transcription

Induction of NF-κB-dependent transcription requires phosphorylation and subsequent degradation of I-κB, an inhibitor of NF-κB, followed by nuclear translocation and DNA binding of NF-κB. Tumor necrosis factor receptor-associated factor 2 (TRAF2) plays a role in NF-κB activation in response to cytoki...

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Detalhes bibliográficos
Main Authors: Bonnard, Madeleine, Mirtsos, Christine, Suzuki, Shinobu, Graham, Kevin, Huang, Jianing, Ng, Michelle, Itié, Annick, Wakeham, Andrew, Shahinian, Arda, Henzel, William J., Elia, Andrew J., Shillinglaw, Wendy, Mak, Tak W., Cao, Zhaodan, Yeh, Wen-Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC314216/
https://ncbi.nlm.nih.gov/pubmed/10990461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.18.4976
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