The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium

OBJECTIVE: In mice, haploinsufficiency of the IGF-1 receptor (IGF-1R(+/−)), at a whole-body level, increases resistance to inflammation and oxidative stress, but the underlying mechanisms are unclear. We hypothesized that by forming insulin-resistant heterodimers composed of one IGF-1Rαβ and one ins...

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Hlavní autoři: Abbas, Afroze, Imrie, Helen, Viswambharan, Hema, Sukumar, Piruthivi, Rajwani, Adil, Cubbon, Richard M., Gage, Matthew, Smith, Jessica, Galloway, Stacey, Yuldeshava, Nadira, Kahn, Matthew, Xuan, Shouhong, Grant, Peter J., Channon, Keith M., Beech, David J., Wheatcroft, Stephen B., Kearney, Mark T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2011
Témata:
Pathophysiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142083/
https://ncbi.nlm.nih.gov/pubmed/21677284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0197
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