The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo

There are currently two distinct models proposed to explain why both MDM2 and MDMX are required in p53 control, with a key difference centered on whether these two p53 inhibitors work together or independently. To test these two competing models, we generated knockin mice expressing a point mutation...

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Autori principali: Huang, Lei, Yan, Zheng, Liao, Xiaodong, Li, Yuan, Yang, Jie, Wang, Zhu-Gang, Zuo, Yong, Kawai, Hidehiko, Shadfan, Miriam, Ganapathy, Suthakar, Yuan, Zhi-Min
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141917/
https://ncbi.nlm.nih.gov/pubmed/21730163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102309108
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