The Role of Hypoxia-Inducible Factor-1α in Acetaminophen Hepatotoxicity

Hypoxia-inducible factor-1α (HIF-1α) is a critical transcription factor that controls oxygen homeostasis in response to hypoxia, inflammation, and oxidative stress. HIF has been implicated in the pathogenesis of liver injury in which these events play a role, including acetaminophen (APAP) overdose,...

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Main Authors: Sparkenbaugh, Erica M., Saini, Yogesh, Greenwood, Krista K., LaPres, John J., Luyendyk, James P., Copple, Bryan L., Maddox, Jane F., Ganey, Patricia E., Roth, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2011
Fag:
Toxicology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141908/
https://ncbi.nlm.nih.gov/pubmed/21576378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.180521
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