DNA-Dependent Protein Kinase and Ataxia Telangiectasia Mutated (ATM) Promote Cell Survival in Response to NK314, a Topoisomerase IIα Inhibitor

4-Hydroxy-5-methoxy-2,3-dihydro-1H-[1,3]benzodioxolo[5,6-c]pyrrolo[1,2-f]-phenanthridium chloride (NK314) is a benzo[c] phenanthridine alkaloid that inhibits topoisomerase IIα, leading to the generation of DNA double-strand breaks (DSBs) and activating the G(2) checkpoint pathway. The purpose of the...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Guo, Lei, Liu, Xiaojun, Jiang, Yingjun, Nishikawa, Kiyohiro, Plunkett, William
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Pharmacology and Experimental Therapeutics 2011
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141888/
https://ncbi.nlm.nih.gov/pubmed/21546556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.057125
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