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Stable Brain ATM Message and Residual Kinase-Active ATM Protein in Ataxia-Telangiectasia
The gene that is mutated in ataxia-telangiectasia (A-T), ATM, is catalytically activated in response to DNA damage. Yet a full accounting for the CNS deficits in human A-T or its mouse models remains elusive. We have analyzed the CNS phenotypes of two mouse Atm alleles—Atm(tm1Bal) (Bal) and Atm(tm1A...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Society for Neuroscience
2011
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3109425/ https://ncbi.nlm.nih.gov/pubmed/21593342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0778-11.2011 |
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