NK314, a Topoisomerase II Inhibitor That Specifically Targets the α Isoform

Topoisomerase II (Top2) is a ubiquitous nuclear enzyme that relieves torsional stress in chromosomal DNA during various cellular processes. Agents that target Top2, involving etoposide, doxorubicin, and mitoxantrone, are among the most effective anticancer drugs used in the clinic. Mammalian cells p...

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Detalles Bibliográficos
Autores principales: Toyoda, Eriko, Kagaya, Shigehide, Cowell, Ian G., Kurosawa, Aya, Kamoshita, Keiichi, Nishikawa, Kiyohiro, Iiizumi, Susumu, Koyama, Hideki, Austin, Caroline A., Adachi, Noritaka
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259784/
https://ncbi.nlm.nih.gov/pubmed/18596031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803936200
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