NK314, a Topoisomerase II Inhibitor That Specifically Targets the α Isoform

Topoisomerase II (Top2) is a ubiquitous nuclear enzyme that relieves torsional stress in chromosomal DNA during various cellular processes. Agents that target Top2, involving etoposide, doxorubicin, and mitoxantrone, are among the most effective anticancer drugs used in the clinic. Mammalian cells p...

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Detalhes bibliográficos
Main Authors: Toyoda, Eriko, Kagaya, Shigehide, Cowell, Ian G., Kurosawa, Aya, Kamoshita, Keiichi, Nishikawa, Kiyohiro, Iiizumi, Susumu, Koyama, Hideki, Austin, Caroline A., Adachi, Noritaka
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259784/
https://ncbi.nlm.nih.gov/pubmed/18596031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803936200
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