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Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors
G protein-coupled receptors (GPCRs) are key regulators of cell physiology and control processes ranging from glucose homeostasis to contractility of the heart. A major mechanism for the desensitization of activated GPCRs is their phosphorylation by GPCR kinases (GRKs). Overexpression of GRK2 is stro...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3141885/ https://ncbi.nlm.nih.gov/pubmed/21596927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.071522 |
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