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Molecular mechanism for inhibition of G protein-coupled receptor kinase 2 by a selective RNA aptamer
Cardiovascular homeostasis is maintained in part by the rapid desensitization of activated heptahelical receptors that have been phosphorylated by G protein-coupled receptor kinase 2 (GRK2). However, during chronic heart failure GRK2 is upregulated and believed to contribute to disease progression....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3418449/ https://ncbi.nlm.nih.gov/pubmed/22727813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.05.002 |
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