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Structural Mimicry of the α-Helix in Aqueous Solution with an Isoatomic α/β/γ-Peptide Backbone
Artificial mimicry of α-helices offers a basis for development of protein-protein interaction antagonists. Here we report a new type of unnatural peptidic backbone, containing α-, β- and γ-amino acid residues in an αγααβα repeat pattern, for this purpose. This unnatural hexad has the same number of...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3141811/ https://ncbi.nlm.nih.gov/pubmed/21520956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja202175a |
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