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Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice

Thymic selection adjusts the reactivity of the peripheral T cell repertoire to maximize recognition of pathogens and minimize stimulation by innocuous substances and self-antigen. The study of molecules implicated in T cell activation often involves the generation of knockout (-/-) mice. In many ins...

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Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Kissler, Stephan, Lu, Linrong, Cantor, Harvey
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2003
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314164/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14694195/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307202101
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