Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice
Thymic selection adjusts the reactivity of the peripheral T cell repertoire to maximize recognition of pathogens and minimize stimulation by innocuous substances and self-antigen. The study of molecules implicated in T cell activation often involves the generation of knockout (-/-) mice. In many ins...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314164/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14694195/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307202101 |
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