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Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice
Thymic selection adjusts the reactivity of the peripheral T cell repertoire to maximize recognition of pathogens and minimize stimulation by innocuous substances and self-antigen. The study of molecules implicated in T cell activation often involves the generation of knockout (-/-) mice. In many ins...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC314164/ https://ncbi.nlm.nih.gov/pubmed/14694195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307202101 |
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