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Sequence determinants of amyloid fibril formation

The establishment of rules that link sequence and amyloid feature is critical for our understanding of misfolding diseases. To this end, we have performed a saturation mutagenesis analysis on the de novo-designed amyloid peptide STVIIE (1). The positional scanning mutagenesis has revealed that there...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: López de la Paz, Manuela, Serrano, Luis
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2003
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314143/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14691246/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2634884100
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