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Sequence determinants of amyloid fibril formation
The establishment of rules that link sequence and amyloid feature is critical for our understanding of misfolding diseases. To this end, we have performed a saturation mutagenesis analysis on the de novo-designed amyloid peptide STVIIE (1). The positional scanning mutagenesis has revealed that there...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC314143/ https://ncbi.nlm.nih.gov/pubmed/14691246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2634884100 |
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