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Amyloid fibril formation by an SH3 domain

The SH3 domain is a well characterized small protein module with a simple fold found in many proteins. At acid pH, the SH3 domain (PI3-SH3) of the p85α subunit of bovine phosphatidylinositol 3-kinase slowly forms a gel that consists of typical amyloid fibrils as assessed by electron microscopy, a Co...

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Detalhes bibliográficos
Main Authors: Guijarro, J. Iñaki, Sunde, Margaret, Jones, Jonathan A., Campbell, Iain D., Dobson, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22470/
https://ncbi.nlm.nih.gov/pubmed/9539718
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