A new polymorphism of human amylin fibrils with similar protofilaments and a conserved core
Summary: Pancreatic amyloid deposits composed of a fibrillar form of the human islet amyloid polypeptide (hIAPP) are the pathological hallmark of type 2 diabetes (T2D). Although various cryo-EM structures of polymorphic hIAPP fibrils were reported, the underlying polymorphic mechanism of hIAPP remai...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Elsevier
2022-12-01
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| Edice: | iScience |
| Témata: | |
| On-line přístup: | http://www.sciencedirect.com/science/article/pii/S2589004222019782 |
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