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A deoxyribozyme that harnesses light to repair thymine dimers in DNA

In vitro selection was used to investigate whether nucleic acid enzymes are capable of catalyzing photochemical reactions. The reaction chosen was photoreactivation of thymine cyclobutane dimers in DNA by using serotonin as cofactor and light of wavelengths longer than the absorption spectrum of DNA...

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Autors principals: Chinnapen, Daniel J.-F., Sen, Dipankar
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC314139/
https://ncbi.nlm.nih.gov/pubmed/14691255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305943101
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