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Direct observation of thymine dimer repair in DNA by photolyase
Photolyase uses light energy to split UV-induced cyclobutane dimers in damaged DNA, but its molecular mechanism has never been directly revealed. Here, we report the direct mapping of catalytic processes through femtosecond synchronization of the enzymatic dynamics with the repair function. We obser...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2005
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1283438/ https://ncbi.nlm.nih.gov/pubmed/16169906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506586102 |
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