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Direct observation of thymine dimer repair in DNA by photolyase

Photolyase uses light energy to split UV-induced cyclobutane dimers in damaged DNA, but its molecular mechanism has never been directly revealed. Here, we report the direct mapping of catalytic processes through femtosecond synchronization of the enzymatic dynamics with the repair function. We obser...

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Detalhes bibliográficos
Principais autores: Kao, Ya-Ting, Saxena, Chaitanya, Wang, Lijuan, Sancar, Aziz, Zhong, Dongping
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283438/
https://ncbi.nlm.nih.gov/pubmed/16169906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506586102
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