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Understanding the Origins of Bacterial Resistance to Aminoglycosides through Molecular Dynamics Mutational Study of the Ribosomal A-Site
Paromomycin is an aminoglycosidic antibiotic that targets the RNA of the bacterial small ribosomal subunit. It binds in the A-site, which is one of the three tRNA binding sites, and affects translational fidelity by stabilizing two adenines (A1492 and A1493) in the flipped-out state. Experiments hav...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2011
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3140962/ https://ncbi.nlm.nih.gov/pubmed/21814503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002099 |
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