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Molecular dynamics study of the ribosomal A-site
Many aminoglycosidic antibiotics target the A-site of 16S RNA in the small ribosomal subunit and affect the fidelity of protein translation in bacteria. Upon binding aminoglycosides displace two adenines (A1492 and A1493 for E. coli numbering) that are involved in tRNA anticodon loop recognition. Th...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2665305/ https://ncbi.nlm.nih.gov/pubmed/18973356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp806814s |
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