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Association of aminoglycosidic antibiotics with the ribosomal A-site studied with Brownian dynamics

Brownian dynamics methodology was applied to simulate the encounter of aminoglycosidic antibiotics with the ribosomal A-site RNA. Studied antibiotics included neamine, neomycin, ribostamycin and paromomycin which differ in chemical structure, the number of pseudo-sugar rings and the net charge. The...

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Detalhes bibliográficos
Main Authors: Długosz, Maciej, Antosiewicz, Jan M., Trylska, Joanna
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612597/
https://ncbi.nlm.nih.gov/pubmed/19343095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct700210n
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