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Association of aminoglycosidic antibiotics with the ribosomal A-site studied with Brownian dynamics
Brownian dynamics methodology was applied to simulate the encounter of aminoglycosidic antibiotics with the ribosomal A-site RNA. Studied antibiotics included neamine, neomycin, ribostamycin and paromomycin which differ in chemical structure, the number of pseudo-sugar rings and the net charge. The...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2612597/ https://ncbi.nlm.nih.gov/pubmed/19343095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct700210n |
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