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Sidechain Biology and the Immunogenicity of PDC-E2, the Major Autoantigen of Primary Biliary Cirrhosis

The E2 component of mitochondrial pyruvate dehydrogenase complex (PDC-E2) is the immunodominant autoantigen of primary biliary cirrhosis. Whereas lipoylation of PDC-E2 is essential for enzymatic activity and predominates under normal conditions, other biochemical systems exist that also target the l...

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Autori principali: Mao, Tin K., Davis, Paul A., Odin, Joseph A., Coppel, Ross L., Gershwin, M. Eric
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140764/
https://ncbi.nlm.nih.gov/pubmed/15558739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.20491
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