Combinatorial autoantibodies to dihydrolipoamide acetyltransferase, the major autoantigen of primary biliary cirrhosis.

mRNA from a regional lymph node of a patient with primary biliary cirrhosis (PBC) was used to construct a combinatorial immunoglobulin library in the lambda phage vector system. Six human monoclonal IgG Fab clones (LC1-LC6) specific for the major autoantigen of PBC--dihydrolipoamide acetyltransferas...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Cha, S, Leung, P S, Gershwin, M E, Fletcher, M P, Ansari, A A, Coppel, R L
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1993
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46121/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8460168/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.6.2527
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