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Truncated tau and Aβ cooperatively impair mitochondria in primary neurons
Mitochondrial dysfunction is likely a significant contributing factor to Alzheimer disease pathogenesis, and both Aβ and pathological forms of tau may contribute to this impairment. Cleavage of tau at Asp421 occurs early in Alzheimer disease, and Asp421-cleaved tau likely negatively impacts neuronal...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3140623/ https://ncbi.nlm.nih.gov/pubmed/21450370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2011.02.007 |
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