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Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease

BACKGROUND: Mitochondrial impairment has been implicated in the pathogenesis of Huntington’s disease (HD). However, how mutant huntingtin impairs mitochondrial function and thus contributes to HD has not been fully elucidated. In this study, we used striatal cells expressing wild type (STHdh(Q7/Q7))...

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Detalhes bibliográficos
Main Authors: Quintanilla, Rodrigo A, Jin, Youngnam N, von Bernhardi, Rommy, Johnson, Gail VW
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878840/
https://ncbi.nlm.nih.gov/pubmed/24330821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-8-45
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