Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells

Mitochondria are highly specialized organelles essential for the synapse, and their impairment contributes to the neurodegeneration in Alzheimer’s disease (AD). Previously, we studied the role of caspase-3–cleaved tau in mitochondrial dysfunction in AD. In neurons, the presence of this AD-relevant t...

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Vydáno v:Front Cell Neurosci
Hlavní autoři: Quintanilla, Rodrigo A., Tapia-Monsalves, Carola, Vergara, Erick H., Pérez, María José, Aranguiz, Alejandra
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Cellular Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406829/
https://ncbi.nlm.nih.gov/pubmed/32848607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.00175
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