Over-expression of Ste20-related proline/alanine rich kinase (SPAK) exacerbates experimental colitis in mice

Inflammatory bowel disease (IBD), mainly Crohn’s disease (CD) and ulcerative colitis (UC), are characterized by epithelial barrier disruption and altered immune regulation. Colonic Ste20-like proline/alanine-rich kinase (SPAK) plays a role in intestinal inflammation, but its underlying mechanisms ne...

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Main Authors: Yan, Yutao, Laroui, Hamed, Ingersoll, Sarah A., Ayyadurai, Saravanan, Charania, Moiz, Yang, Stephen, Dalmasso, Guillaume, Obertone, Tracy S., Nguyen, Hang, Sitaraman, Shanthi V., Merlin, Didier
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140558/
https://ncbi.nlm.nih.gov/pubmed/21705622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002910
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