Over-expression of Ste20-related proline/alanine rich kinase (SPAK) exacerbates experimental colitis in mice

Inflammatory bowel disease (IBD), mainly Crohn’s disease (CD) and ulcerative colitis (UC), are characterized by epithelial barrier disruption and altered immune regulation. Colonic Ste20-like proline/alanine-rich kinase (SPAK) plays a role in intestinal inflammation, but its underlying mechanisms ne...

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Detalhes bibliográficos
Main Authors: Yan, Yutao, Laroui, Hamed, Ingersoll, Sarah A., Ayyadurai, Saravanan, Charania, Moiz, Yang, Stephen, Dalmasso, Guillaume, Obertone, Tracy S., Nguyen, Hang, Sitaraman, Shanthi V., Merlin, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140558/
https://ncbi.nlm.nih.gov/pubmed/21705622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002910
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