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Glucose Autoxidation Induces Functional Damage to Proteins via Modification of Critical Arginine Residues()

Non-enzymatic modification of proteins in hyperglycemia is a major mechanism causing diabetic complications. These modifications can have pathogenic consequences when they target active site residues, thus affecting protein function. In the present study, we examined the role of glucose autoxidation...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chetyrkin, Sergei, Mathis, Missy, Pedchenko, Vadim, Sanchez, Otto A., McDonald, W. Hayes, Hachey, David L., Madu, Hartman, Stec, Donald, Hudson, Billy, Voziyan, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140462/
https://ncbi.nlm.nih.gov/pubmed/21661747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200757d
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