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Glucose Autoxidation Induces Functional Damage to Proteins via Modification of Critical Arginine Residues()

Non-enzymatic modification of proteins in hyperglycemia is a major mechanism causing diabetic complications. These modifications can have pathogenic consequences when they target active site residues, thus affecting protein function. In the present study, we examined the role of glucose autoxidation...

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Hlavní autoři: Chetyrkin, Sergei, Mathis, Missy, Pedchenko, Vadim, Sanchez, Otto A., McDonald, W. Hayes, Hachey, David L., Madu, Hartman, Stec, Donald, Hudson, Billy, Voziyan, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140462/
https://ncbi.nlm.nih.gov/pubmed/21661747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200757d
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