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Glucose Autoxidation Induces Functional Damage to Proteins via Modification of Critical Arginine Residues()

Non-enzymatic modification of proteins in hyperglycemia is a major mechanism causing diabetic complications. These modifications can have pathogenic consequences when they target active site residues, thus affecting protein function. In the present study, we examined the role of glucose autoxidation...

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Détails bibliographiques
Auteurs principaux: Chetyrkin, Sergei, Mathis, Missy, Pedchenko, Vadim, Sanchez, Otto A., McDonald, W. Hayes, Hachey, David L., Madu, Hartman, Stec, Donald, Hudson, Billy, Voziyan, Paul
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140462/
https://ncbi.nlm.nih.gov/pubmed/21661747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200757d
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